Subtle differences in antibody responses and hypermutation of lambda light chains in mice with a disrupted chi constant region.

doi:10.1002/eji.1830250806

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Article

Subtle differences in antibody responses and hypermutation of lambda light chains in mice with a disrupted chi constant region.

European journal of immunology - 1 Aug 1995

Zou X, Xian J, Popov A V, Rosewell I R, Müller M, Brüggemann M

Abstract excerpt

Analysis of lambda light chain use in normal mice is made difficult by the dominant chi light chain repertoire. We produced mice rendered deficient in chi light chain expression by gene targeting and focused on questions concerned with the generation of lambda light chain diversity. Whilst these mice compensate the chi deficiency with increased lambda liters, and their Ig level is therefore not significantly...

Topics

Amino Acid Sequence
Animals
Antibodies, Monoclonal
Antibody Formation
B-Lymphocytes
Base Sequence
Immunoglobulin Constant Regions
Immunoglobulin lambda-Chains
Mice
Mice, Inbred BALB C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

Mice, Inbred CBA

Mice, Mutant Strains

Molecular Sequence Data

Mutation

Peyer's Patches

Source

Open in PubMed

Identifiers

PMID: 7664778
DOI: 10.1002/eji.1830250806

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7664778-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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