Article
Genetic determinants of sensitivity to beryllium in mice.
Journal of immunotoxicology - 1 Jun 2009
Tarantino-Hutchison Lauren M, Sorrentino Claudio, Nadas Arthur, Zhu Yiwen, Rubin Edward M, Tinkle Sally S, Weston Ainsley, Gordon Terry
Abstract excerpt
Chronic beryllium disease (CBD), an irreversible, debilitating granulomatous lung disease is caused by exposure to beryllium. This occupational hazard occurs in primary production and machining of Be-metal, BeO, beryllium - containing alloys, and other beryllium products. CBD begins as an MHC Class II-restricted, T(H)1 hypersensitivity, and the Human Leukocyte Antigen, HLA-DPB1E(69), is associated with risk of...
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