Article
Restricted V gene repertoire in the secondary response to insulin in young BALB/c mice.
Journal of immunology (Baltimore, Md. : 1950) - 1 May 1997
Tikhomirov OYu, Thomas J W
Abstract excerpt
Previous data on the genetic origin of insulin Abs in BALB/c mice are derived from immune responses following a single or primary immunization. This primary response, however, may not represent the repertoire established by chronic insulin administration, which is used in the treatment of diabete...
Topics
- Age Factors
- Amino Acid Sequence
- Animals
- Antibodies, Monoclonal
- Antibody Affinity
- Base Sequence
- Genes, Immunoglobulin
- Immunoglobulin kappa-Chains
- Immunologic Memory
- Insulin
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Mutation
- Sequence Alignment
- Sequence Homology, Amino Acid
- Sequence Homology, Nucleic Acid