Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Restricted V gene repertoire in the secondary response to insulin in young BALB/c mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 1997

Tikhomirov OYu, Thomas J W

Abstract excerpt

Previous data on the genetic origin of insulin Abs in BALB/c mice are derived from immune responses following a single or primary immunization. This primary response, however, may not represent the repertoire established by chronic insulin administration, which is used in the treatment of diabetes mellitus and in protocols to alter beta cell destruction in pre-insulin-dependent (type 1) diabetes mellitus. In this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Antibodies, Monoclonal
Share to Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutation

Share to Sequence Homology, Amino Acid

Share to Sequence Homology, Nucleic Acid

Source

Identifiers

PMID: 9126991

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Restricted V gene repertoire in the secondary response to insulin in young BALB/c mice.PMID 9126991Read ↗

The BALB/c secondary response to the Sb site of influenza virus hemagglutinin. Nonrandom silent mutation and unequal numbers of VH and Vk mutations.Semantic proximity Read ↗

Variable region sequences of pathogenic anti-mouse red blood cell autoantibodies from autoimmune NZB mice.Semantic proximity Read ↗

Multiple germline kappa light chains generate anti-insulin B cells in nonobese diabetic mice.Semantic proximity Read ↗

Extensive somatic mutation in the Ig heavy chain V genes in a late primary anti-hapten immune response.Semantic proximity Read ↗

Correlation between the amino acid position of arginine in VH-CDR3 and specificity for native DNA among autoimmune antibodiesSemantic proximity Read ↗

Restricted CDR3 length of the heavy chain is characteristic of six randomly isolated disease-associated VH J558+ IgM autoantibodies in lupus prone motheaten mice.Semantic proximity Read ↗

Monoclonal immunoglobulin A derived from peritoneal B cells is encoded by both germ line and somatically mutated VH genes and is reactive with commensal bacteria.Semantic proximity Read ↗

Germline diversity of the expressed BALB/c VhJ558 gene family.Semantic proximity Read ↗

Preference for IgG mAb binding insulin in solution or on surfaces is related to immunoglobulin variable region structures.Semantic proximity Read ↗

Molecular basis of antigen recognition by insulin specific T cell receptor.Semantic proximity Read ↗

Gene family use and somatic mutation in primary and secondary fluorescein-specific IgM antibody responses.Semantic proximity Read ↗

B-cell responses to a peptide epitope: mutations in heavy chain alone lead to maturation of antibody responses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.