Article
VH gene family expression in mice with the xid defect.
The Journal of experimental medicine - 1 Jul 1991
Feng S H, Stein K E
Abstract excerpt
Preferential use of particular VH gene families in the response to specific antigens has been demonstrated in several systems. The lack of responses to certain types of antigens, therefore, could be the result of deletion of or failure to express some VH genes. Because CBA/N mice, which carry the...
Topics
- Animals
- B-Lymphocytes
- Cell Line
- Crosses, Genetic
- DNA Probes
- Female
- Gene Expression
- Genes, Immunoglobulin
- Genotype
- Hybridomas
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Immunologic Deficiency Syndromes
- Lipopolysaccharides
- Male
- Mice
- Mice, Inbred CBA
- Multigene Family