Article
Analysis of the anti-azobenzenearsonate response at the molecular level.
Annales d'immunologie - 1 Jan 2000
Gefter M L, Margolies M N, Near R I, Wysocki L J
Abstract excerpt
We have analysed, at the molecular level, the antibodies associated with the anti-azobenzenearsonate response of A/J and BALB/c mice as well as the genes that encode them. All antibodies expressing the predominant idiotype are derived by somatic mutation from a single VH gene. Antibody molecules express the idiotype regardless of their light chains or the JH segments which encode them. The D segment, however,...
Topics
- Animals
- Antibody Formation
- Azo Compounds
- Base Sequence
- Immunoglobulin Idiotypes
- Mice
- Mice, Inbred BALB C
- Mutation
- p-Azobenzenearsonate