Article
Somatic diversity of the immunoglobulin repertoire is controlled in an isotype-specific manner.
European journal of immunology - 1 Aug 2001
Luger E, Lamers M, Achatz-Straussberger G, Geisberger R, Inführ D, Breitenbach M, Crameri R, Achatz G
Abstract excerpt
We have studied two aspects of the IgE immune response. First, we have compared the kinetics of the IgE response to the T cell-dependent antigen ph-Ox coupled to ovalbumin with that of the IgG1 response and we have assessed the quality of the IgE response. Second, we have studied the generation of somatic diversity, understood as the combined effect of somatic mutation and the selection of D(iversity) and...
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