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Article

A lambda 1 transgene under the control of a heavy chain promoter and enhancer does not undergo somatic hypermutation.

European journal of immunology - 1 Jul 1994

Hengstschläger M, Williams M, Maizels N

Abstract excerpt

To identify cis-acting elements responsible for targeting somatic hypermutation to immunoglobulin variable regions, we generated transgenic mice which carry a rearranged lambda 1 gene regulated by the heavy chain intron enhancer, E mu, and the heavy chain promoter PH186.2 from the VH186.2 variable region. C57BL/6 x SJL founders were bred with C57BL/6 mice to establish a line carrying a single copy of the...

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Source

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PMID: 8026525
DOI: 10.1002/eji.1830240729

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A lambda 1 transgene under the control of a heavy chain promoter and enhancer does not undergo somatic hypermutation.PMID 8026525Read ↗

Lack of somatic mutation in a kappa light chain transgene.Semantic proximity Read ↗

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Somatic hypermutation in mouse lambda chains.Semantic proximity Read ↗

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Somatic hypermutation of a lambda 2 transgene under the control of the lambda enhancer or the heavy chain intron enhancer.Semantic proximity Read ↗

Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: implications for the location of cis-acting elements required for somatic mutation.Semantic proximity Read ↗

Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C kappa and occurs on passenger transgenes.Semantic proximity Read ↗

Ig VH hypermutation is absent in the germinal centers of aged mice.Semantic proximity Read ↗

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Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots.Semantic proximity Read ↗

Somatic mutation in constant regions of mouse lambda 1 light chains.Semantic proximity Read ↗

Affinity maturation leads to differential expression of multiple copies of a kappa light-chain transgene.Semantic proximity Read ↗

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