V(D)J recombination and allelic exclusion of a TCR beta-chain minilocus occurs in the absence of a functional promoter.

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Article

V(D)J recombination and allelic exclusion of a TCR beta-chain minilocus occurs in the absence of a functional promoter.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 1995

Alvarez J D, Anderson S J, Loh D Y

Abstract excerpt

Transcriptional activation of rearranging Ag receptor gene segments has been hypothesized to regulate their accessibility to V(D)J recombination. We analyzed the role of a functional promoter in the rearrangement of the murine TCR beta-chain locus using two transgenic minilocus constructs. These miniloci each contain an unrearranged V beta 8.3 gene. One has a wild-type V beta 8.3 gene, but the other has a V beta...

Topics

Alleles
Animals
Base Sequence
DNA Nucleotidyltransferases
Female
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Genes, Synthetic
Mice
Mice, Inbred BALB C
Mice, Inbred C3H
Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Transgenic

Molecular Sequence Data

Polymerase Chain Reaction

Promoter Regions, Genetic

Receptors, Antigen, T-Cell, alpha-beta

Sequence Alignment

Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 7636187

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7636187-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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