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Article

Distinct control of the frequency and allelic exclusion of the V beta gene rearrangement at the TCR beta locus.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2001

Sieh P, Chen J

Abstract excerpt

Ag receptor gene loci contain many V gene segments, each of which is recombined and expressed at a different frequency and is subject to allelic exclusion. To probe the parameters that mediate the different levels of regulation of V gene rearrangement, a Vbeta gene segment together with 3.6-kb 5' and 0.7-kb 3' flanking sequences was inserted 6.8 kb upstream of the Dbeta1 gene segment in the murine TCRbeta locus....

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Share to Receptors, Antigen, T-Cell, alpha-beta

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Source

Identifiers

PMID: 11489996
DOI: 10.4049/jimmunol.167.4.2121

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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