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Article

Allelic exclusion at DNA rearrangement level is required to prevent coexpression of two distinct T cell receptor beta genes.

The Journal of experimental medicine - 1 Oct 1991

van Meerwijk J P, Romagnoli P, Iglesias A, Bluethmann H, Steinmetz M

Abstract excerpt

In mice double transgenic for functionally rearranged T cell receptor (TCR) V beta 2 and V beta 8.2 genes we found that most T lymphocytes express both TCR beta chains simultaneously. These T cells show no abnormality in thymic selection in vivo and their TCRs are capable of transducing activation signals in vitro. These results indicate that multispecific T cells may appear in the periphery if allelic exclusion...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 1655946
DOI: 10.1084/jem.174.4.815
PMCID: PMC2118971

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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