Article
Allelic exclusion at DNA rearrangement level is required to prevent coexpression of two distinct T cell receptor beta genes.
The Journal of experimental medicine - 1 Oct 1991
van Meerwijk J P, Romagnoli P, Iglesias A, Bluethmann H, Steinmetz M
Abstract excerpt
In mice double transgenic for functionally rearranged T cell receptor (TCR) V beta 2 and V beta 8.2 genes we found that most T lymphocytes express both TCR beta chains simultaneously. These T cells show no abnormality in thymic selection in vivo and their TCRs are capable of transducing activatio...
Topics
- Alleles
- Animals
- CD4 Antigens
- CD8 Antigens
- Crosses, Genetic
- Flow Cytometry
- Gene Expression Regulation
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
- Genotype
- Lymph Nodes
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Receptors, Antigen, T-Cell, alpha-beta
- Signal Transduction
- T-Lymphocytes
- Thymus Gland