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Article

Chromosomal position of rearranging gene segments influences allelic exclusion in transgenic mice.

Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 1992

Costa T E, Suh H, Nussenzweig M C

Abstract excerpt

Formation of a complete immunoglobulin heavy-chain transcription unit involves the ordered rearrangement of variable (V), diversity (D), and joining (J) region gene segments. In antibody-producing cells, this process is regulated such that only one of two antibody genes is expressed. Experiments with transgenic mice suggest that this mechanism, known as allelic exclusion, is mediated through the membrane-bound...

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Identifiers

PMID: 1372438
DOI: 10.1073/pnas.89.6.2205
PMCID: PMC48625

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Chromosomal position of rearranging gene segments influences allelic exclusion in transgenic mice.PMID 1372438Read ↗

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