Article
Chromosomal position of rearranging gene segments influences allelic exclusion in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 1992
Costa T E, Suh H, Nussenzweig M C
Abstract excerpt
Formation of a complete immunoglobulin heavy-chain transcription unit involves the ordered rearrangement of variable (V), diversity (D), and joining (J) region gene segments. In antibody-producing cells, this process is regulated such that only one of two antibody genes is expressed. Experiments...
Topics
- Alleles
- Animals
- B-Lymphocytes
- Base Sequence
- Chromosome Mapping
- DNA
- Gene Rearrangement, B-Lymphocyte
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Joining Region
- Immunoglobulin M
- Immunoglobulin Variable Region
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Oligodeoxyribonucleotides
- Polymerase Chain Reaction
- RNA