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Article

Allelic exclusion of a T cell receptor-beta minilocus.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 1991

van Meerwijk J P, Iglesias A, Hansen-Hagge T, Bluethmann H, Steinmetz M

Abstract excerpt

A TCR-beta minilocus in germline configuration (beta M) has previously been shown to undergo rearrangement and expression in transgenic mice. To study allelic exclusion of TCR miniloci, several beta M transgenic mouse lines were generated and crossed with mice transgenic for a functionally rearranged TCR V beta 2 gene (beta R). PCR analysis of beta M beta R double transgenic mice revealed almost complete...

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PMID: 1655909

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Allelic exclusion of a T cell receptor-beta minilocus.PMID 1655909Read ↗

V(D)J recombination and allelic exclusion of a TCR beta-chain minilocus occurs in the absence of a functional promoter.Semantic proximity Read ↗

Allelic exclusion at DNA rearrangement level is required to prevent coexpression of two distinct T cell receptor beta genes.Semantic proximity Read ↗

Lack of allelic exclusion permits autoreactive B cells to escape deletion.Semantic proximity Read ↗

T cell receptor (TcR) beta chain transgenic mice: studies on allelic exclusion and on the TcR+ gamma/delta population.Semantic proximity Read ↗

Allelic exclusion in pTalpha-deficient mice: no evidence for cell surface expression of two T cell receptor (TCR)-beta chains, but less efficient inhibition of endogeneous Vbeta--> (D)Jbeta rearrangements in the presence of a functional TCR-beta transgene.Semantic proximity Read ↗

Regulation of TCR alpha and beta gene allelic exclusion during T-cell development.Semantic proximity Read ↗

Expression of immunoglobulin delta chain causes allelic exclusion in transgenic mice.Semantic proximity Read ↗

Maintenance of TCR clonality in T cells expressing genes for two TCR heterodimers.Semantic proximity Read ↗

Distinct control of the frequency and allelic exclusion of the V beta gene rearrangement at the TCR beta locus.Semantic proximity Read ↗

Essential role of the pre-T cell receptor in allelic exclusion of the T cell receptor beta locus.Semantic proximity Read ↗

Germline transcription from T-cell receptor Vbeta gene is uncoupled from allelic exclusion.Semantic proximity Read ↗

Biochemical and functional analyses of chromatin changes at the TCR-beta gene locus during CD4-CD8- to CD4+CD8+ thymocyte differentiation.Semantic proximity Read ↗

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