Article
Abrogation of the allelic exclusion in a T cell receptor beta chain gene transgenic mouse strain.
Immunological investigations - 1 Nov 1995
Mazda O, Aiba Y, Hattori N, Li M, Fujimoto S, Davis M M, Katsura Y
Abstract excerpt
The expression of endogenous T cell receptor (TcR) beta chains in a TcR beta chain gene transgenic mouse (TGM) strain was examined. Unlike many other TGM strains reported, a considerable proportion of T cells from the thymus and spleen as well as organ cultured fetal thymus from our TGM express endogenous TCR beta chains on their surface. Compatible with this was the elucidation of VDJ rearrangement of endogenous...
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