Article
Abrogation of the allelic exclusion in a T cell receptor beta chain gene transgenic mouse strain.
Immunological investigations - 1 Nov 1995
Mazda O, Aiba Y, Hattori N, Li M, Fujimoto S, Davis M M, Katsura Y
Abstract excerpt
The expression of endogenous T cell receptor (TcR) beta chains in a TcR beta chain gene transgenic mouse (TGM) strain was examined. Unlike many other TGM strains reported, a considerable proportion of T cells from the thymus and spleen as well as organ cultured fetal thymus from our TGM express e...
Topics
- Alleles
- Animals
- Cell Line
- Cytochrome c Group
- Enhancer Elements, Genetic
- Female
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
- Immunoglobulin Heavy Chains
- Male
- Mice
- Mice, Inbred AKR
- Mice, Inbred C57BL
- Mice, Transgenic
- Organ Culture Techniques
- Receptors, Antigen, T-Cell, alpha-beta
- T-Lymphocytes
- Thymus Gland