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Article

The T-cell receptor beta variable gene promoter is required for efficient V beta rearrangement but not allelic exclusion.

Molecular and cellular biology - 1 Aug 2004

Ryu Chun Jeih, Haines Brian B, Lee Hye Ran, Kang Yun Hee, Draganov Dobrin D, Lee Minhui, Whitehurst Charles E, Hong Hyo Jeong, Chen Jianzhu

Abstract excerpt

To investigate the role of promoters in regulating variable gene rearrangement and allelic exclusion, we constructed mutant mice in which a 1.2-kb region of the V beta 13 promoter was either deleted (P13(-/-)) or replaced with the simian virus 40 minimal promoter plus five copies of Gal4 DNA sequences (P13(R/R)). In P13(-/-) mice, cleavage, rearrangement, and transcription of V beta 13, but not the flanking V...

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Identifiers

PMID: 15282302
DOI: 10.1128/MCB.24.16.7015-7023.2004
PMCID: PMC479718

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Source receipt: pubmed, retrieved 7 Sept 2026.

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