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Article

Expression of immunoglobulin delta chain causes allelic exclusion in transgenic mice.

Nature - 1 Jan 2000

Iglesias A, Lamers M, Köhler G

Abstract excerpt

Rearrangement of the separated V, D and J segments of immunoglobulin heavy and light chain genes is an ordered and regulated process essential for the production and diversification of antibodies in mammals. Only one allele of the heavy and light chain gene locus is found functionally rearranged in normal B cells. The second allele is either non-functionally or incompletely rearranged, a phenomenon known as...

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PMID: 3120014
DOI: 10.1038/330482a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Expression of immunoglobulin delta chain causes allelic exclusion in transgenic mice.PMID 3120014Read ↗

Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in kappa transgenic mice.Semantic proximity Read ↗

Endogenous Ig production in mu transgenic mice. I. Allelic exclusion at the level of expression.Semantic proximity Read ↗

Chromosomal position of rearranging gene segments influences allelic exclusion in transgenic mice.Semantic proximity Read ↗

Germline transcription from T-cell receptor Vbeta gene is uncoupled from allelic exclusion.Semantic proximity Read ↗

Extended duration of DH-JH rearrangement in immunoglobulin heavy chain transgenic mice: implications for regulation of allelic exclusion.Semantic proximity Read ↗

A critical lineage-nonspecific role for pTalpha in mediating allelic and isotypic exclusion in TCRbeta-transgenic mice.Semantic proximity Read ↗

Lack of allelic exclusion permits autoreactive B cells to escape deletion.Semantic proximity Read ↗

Allelic exclusion of immunoglobulin genes: models and mechanisms.Semantic proximity Read ↗

Distinct control of the frequency and allelic exclusion of the V beta gene rearrangement at the TCR beta locus.Semantic proximity Read ↗

Effect of the presence of transgenic H and L chain genes on B cell development and allelic exclusion.Semantic proximity Read ↗

Posttranscriptional silencing of VbetaDJbetaCbeta genes contributes to TCRbeta allelic exclusion in mammalian lymphocytes.Semantic proximity Read ↗

Variegated transcriptional activation of the immunoglobulin kappa locus in pre-b cells contributes to the allelic exclusion of light-chain expression.Semantic proximity Read ↗

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