Expression of immunoglobulin delta chain causes allelic exclusion in transgenic mice.

doi:10.1038/330482a0

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Article

Expression of immunoglobulin delta chain causes allelic exclusion in transgenic mice.

Nature - 1 Jan 2000

Iglesias A, Lamers M, Köhler G

Abstract excerpt

Rearrangement of the separated V, D and J segments of immunoglobulin heavy and light chain genes is an ordered and regulated process essential for the production and diversification of antibodies in mammals. Only one allele of the heavy and light chain gene locus is found functionally rearranged...

Topics

Alleles
Animals
B-Lymphocytes
DNA
Hybridomas
Immunoglobulin D
Immunoglobulin Heavy Chains
Immunoglobulin delta-Chains
Immunoglobulin kappa-Chains
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Transgenic
Nucleic Acid Hybridization
RNA, Messenger
Spleen

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