Article
Lack of allelic exclusion permits autoreactive B cells to escape deletion.
Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 1994
Iliev A, Spatz L, Ray S, Diamond B
Abstract excerpt
The R4A-gamma 2b transgenic mouse harbors the gene for the gamma 2b heavy chain of an anti-dsDNA Ab. Approximately 80% of B cells expressing the transgene display allelic exclusion. Although the transgenic mice have little to no detectable serum anti-DNA activity, splenic B cells can be stimulated in vitro with LPS to secrete anti-DNA Ab. Hybridomas derived from LPS-stimulated splenic B cells were analyzed for...
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