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Article

Germline transcription from T-cell receptor Vbeta gene is uncoupled from allelic exclusion.

The EMBO journal - 2 May 2007

Jia Jingquan, Kondo Motonari, Zhuang Yuan

Abstract excerpt

Allelic exclusion operates in B and T lymphocytes to ensure clonal expression of antigen receptors after V(D)J recombination. Germline transcription, which proceeds V(D)J recombination, has been postulated to provide an instructive signal for allelic exclusion. Here, we use a genetic marker to track germline transcription from a Vbeta gene within the TCRbeta locus. We find that developing thymocytes exhibit...

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Identifiers

PMID: 17410206
DOI: 10.1038/sj.emboj.7601671
PMCID: PMC1864970

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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