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Article

Poor quality Vβ recombination signal sequences stochastically enforce TCRβ allelic exclusion.

The Journal of experimental medicine - 7 Sept 2020

Wu Glendon S, Yang-Iott Katherine S, Klink Morgann A, Hayer Katharina E, Lee Kyutae D, Bassing Craig H

Abstract excerpt

The monoallelic expression of antigen receptor (AgR) genes, called allelic exclusion, is fundamental for highly specific immune responses to pathogens. This cardinal feature of adaptive immunity is achieved by the assembly of a functional AgR gene on one allele, with subsequent feedback inhibition of V(D)J recombination on the other allele. A range of epigenetic mechanisms have been implicated in sequential...

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Source

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Identifiers

PMID: 32526772
DOI: 10.1084/jem.20200412
PMCID: PMC7478721

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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