Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of direct and inverted DJH rearrangements in a human Ig heavy chain transgenic minilocus.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1995

Tuaillon N, Miller A B, Tucker P W, Capra J D

Abstract excerpt

D to JH rearrangement can occur either by a deletional or an inversional mechanism. In this study, we have analyzed deletional and inversional D to JH recombination in a human Ig heavy chain transgenic minilocus. The analysis of these events in a transgenic minilocus rather than in vivo in the human is simplified by the presence of a limited number of well defined VH, D, and JH gene segments in the minilocus. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Cloning, Molecular
Share to DNA

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutation

Share to Recombination, Genetic

Share to Sequence Homology, Nucleic Acid

Source

Identifiers

PMID: 7759881

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of direct and inverted DJH rearrangements in a human Ig heavy chain transgenic minilocus.PMID 7759881Read ↗

Biased utilization of DHQ52 and JH4 gene segments in a human Ig transgenic minilocus is independent of antigenic selection.Semantic proximity Read ↗

Indirect and direct evidence for DNA double-strand breaks in hypermutating immunoglobulin genes.Semantic proximity Read ↗

Dominance of intrinsic genetic factors in shaping the human immunoglobulin Vlambda repertoire.Semantic proximity Read ↗

Human immunoglobulin transgenes undergo rearrangement, somatic mutation and class switching in mice that lack endogenous IgM.Semantic proximity Read ↗

High-level rearrangement and transcription of yeast artificial chromosome-based mouse Ig kappa transgenes containing distal regions of the contig.Semantic proximity Read ↗

MECHANISM AND CONTROL OF V(D)J RECOMBINATION AT THE IMMUNOGLOBULIN HEAVY CHAIN LOCUSSemantic proximity Read ↗

Somatic hypermutation of immunoglobulin ĸ light chain genesSemantic proximity Read ↗

Analysis of hypermutation in immunoglobulin heavy chain passenger transgenes.Semantic proximity Read ↗

Cellular and molecular studies of B cells exhibiting reverse somatic mutation throughout life.Semantic proximity Read ↗

V(D)J recombination and allelic exclusion of a TCR beta-chain minilocus occurs in the absence of a functional promoter.Semantic proximity Read ↗

Somatic generation of hybrid antibody H chain genes in transgenic mice via interchromosomal gene conversion.Semantic proximity Read ↗

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.