Article
Allele epsilon 4 of apolipoprotein E shows a dose effect on age at onset of Pick disease.
Experimental neurology - 1 Dec 1995
Farrer L A, Abraham C R, Volicer L, Foley E J, Kowall N W, McKee A C, Wells J M
Abstract excerpt
Pick disease is a rare progressive dementing illness characterized by severe atrophy of the frontal and temporal lobes. Clinically, Pick disease may be difficult to distinguish from Alzheimer disease (AD). The fact that Pick disease is often familial, and the evidence suggesting that the epsilon 4 allele of apolipoprotein E (ApoE) is a risk factor for AD and possibly other dementias, prompted us to study ApoE...
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