Reduced apolipoprotein epsilon 4 allele frequency in the oldest old Alzheimer's patients and cognitively normal individuals.

doi:10.1212/wnl.44.8.1513

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Article

Reduced apolipoprotein epsilon 4 allele frequency in the oldest old Alzheimer's patients and cognitively normal individuals.

Neurology - 1 Aug 1994

Rebeck G W, Perls T T, West H L, Sodhi P, Lipsitz L A, Hyman B T

Abstract excerpt

Recent genetic studies show that the apolipoprotein E epsilon 4 allele (ApoE-epsilon 4) is a risk factor for Alzheimer's disease (AD). If ApoE-epsilon 4 individuals develop AD as they get older, we would expect a decrease in ApoE-epsilon 4 allele frequency with increasing age. We found a marked d...

Topics

Aged
Aged, 80 and over
Aging
Alleles
Alzheimer Disease
Apolipoproteins E
Base Sequence
Female
Genotype
Humans
Male
Molecular Sequence Data
Regression Analysis

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