Influence of the apolipoprotein E genotype on amyloid deposition and neurofibrillary tangle formation in Alzheimer's disease.

doi:10.1016/0306-4522(95)00331-c

Back to search

Article

Influence of the apolipoprotein E genotype on amyloid deposition and neurofibrillary tangle formation in Alzheimer's disease.

Neuroscience - 1 Dec 1995

Nagy Z, Esiri M M, Jobst K A, Johnston C, Litchfield S, Sim E, Smith A D

Abstract excerpt

The effect of the apolipoprotein E genotype on the development of late onset Alzheimer's disease is still debated. Neuropathological studies of Alzheimer's disease have found a great extent of amyloid deposition in cortex and blood vessel walls in association with the apolipoprotein E epsilon 4 g...

Topics

Aged
Aged, 80 and over
Alleles
Alzheimer Disease
Amyloid
Apolipoprotein E2
Apolipoprotein E3
Apolipoprotein E4
Apolipoproteins E
Female
Genotype
Humans
Male
Middle Aged
Neurites
Neurofibrillary Tangles

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.