Article
Apolipoprotein E epsilon4 allele has no effect on age at onset or duration of disease in cases of frontotemporal dementia with pick- or microvacuolar-type histology.
Experimental neurology - 1 Jun 2000
Pickering-Brown S M, Owen F, Isaacs A, Snowden J, Varma A, Neary D, Furlong R, Daniel S E, Cairns N J, Mann D M
Abstract excerpt
Frontotemporal dementia (FTD) is the second most common cause of presenile dementia. Here we have investigated the frequency of the epsilon4 allele of the Apolipoprotein (APOE) gene in FTD and in other non-Alzheimer forms of dementia related to FTD such as Motor Neurone disease dementia, semantic dementia, progressive aphasia, progressive supranuclear palsy, and corticobasal degeneration. In none of these...
Topics
- Adult
- Age of Onset
- Aged
- Aged, 80 and over
- Alleles
- Apolipoprotein E4
- Apolipoproteins E
- Chi-Square Distribution
- Dementia
- Female
- Humans
- Male
- Middle Aged
- Pick Disease of the Brain