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Article

The apolipoprotein E epsilon4 allele frequency is normal in fronto-temporal dementia, but correlates with age at onset of disease.

Neuroscience letters - 18 Apr 1997

Minthon L, Hesse C, Sjögren M, Englund E, Gustafson L, Blennow K

Abstract excerpt

The apolipoprotein (apoE) epsilon4 allele was studied in fronto-temporal dementia (FTD), a diagnostic category including the specific disorders Pick's disease and frontal lobe degeneration of non-Alzheimer type (FLD). These dementing diseases have neuronal and synaptic degeneration in common with Alzheimer's disease (AD), for which the presence of the apoE epsilon4 allele is a known risk factor, and lowers the...

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Identifiers

PMID: 9153643
DOI: 10.1016/s0304-3940(97)00230-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The apolipoprotein E epsilon4 allele frequency is normal in fronto-temporal dementia, but correlates with age at onset of disease.PMID 9153643Read ↗

The apolipoprotein E epsilon4 allele is not a significant risk factor for frontotemporal dementia.Semantic proximity Read ↗

Apolipoprotein E epsilon4 allele has no effect on age at onset or duration of disease in cases of frontotemporal dementia with pick- or microvacuolar-type histology.Semantic proximity Read ↗

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The apolipoprotein E epsilon4 allele selectively increases the risk of frontotemporal lobar degeneration in males.Semantic proximity Read ↗

Allele epsilon 4 of apolipoprotein E shows a dose effect on age at onset of Pick disease.Semantic proximity Read ↗

Apolipoprotein E and Alzheimer disease: an update on genetic and functional analyses.Semantic proximity Read ↗

Gender and age modify the association between APOE and AD-related neuropathology.Semantic proximity Read ↗

Presence of the apolipoprotein E type epsilon 4 allele is not associated with neurofibrillary pathology or biochemical changes to tau protein.Semantic proximity Read ↗

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