The apolipoprotein E epsilon4 allele frequency is normal in fronto-temporal dementia, but correlates with age at onset of disease.

doi:10.1016/s0304-3940(97)00230-9

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Article

The apolipoprotein E epsilon4 allele frequency is normal in fronto-temporal dementia, but correlates with age at onset of disease.

Neuroscience letters - 18 Apr 1997

Minthon L, Hesse C, Sjögren M, Englund E, Gustafson L, Blennow K

Abstract excerpt

The apolipoprotein (apoE) epsilon4 allele was studied in fronto-temporal dementia (FTD), a diagnostic category including the specific disorders Pick's disease and frontal lobe degeneration of non-Alzheimer type (FLD). These dementing diseases have neuronal and synaptic degeneration in common with...

Topics

Adult
Age of Onset
Aged
Alleles
Apolipoprotein E4
Apolipoproteins E
Dementia
Female
Frontal Lobe
Humans
Male
Middle Aged
Temporal Lobe

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