Article
Association of apolipoprotein epsilon 4 allele and neuropathologic findings in patients with dementia.
Acta neuropathologica - 1 Jan 1995
Martinoli M G, Trojanowski J Q, Schmidt M L, Arnold S E, Fujiwara T M, Lee V M, Hurtig H, Julien J P, Clark C
Abstract excerpt
Apolipoprotein E (APOE) is a lipoprotein expressed in liver and brain as one of three isoforms (APOE 2, APOE 3 and APOE 4). Recent findings suggest that the presence of APOE 4 is associated with an increased risk for both familial Alzheimer's disease and late-onset Alzheimer's disease. We extended these observations by determining the frequency of APOE alleles in patients with pathologically confirmed Alzheimer's...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.