Article
Molecular biology of APO E alleles in Alzheimer's and non-Alzheimer's dementias.
Journal of neural transmission. Supplementum - 1 Jan 1996
Morris C M, Massey H M, Benjamin R, Leake A, Broadbent C, Griffiths M, Lamb H, Brown A, Ince P G, Tyrer S, Thompson P, McKeith I G, Edwardson J A, Perry R H, Perry E K
Abstract excerpt
Current research into the aetiology of the dementias is focused upon genetic factors which give rise to the disease process. Recently the Apolipoprotein E gene (APO E) and in particular the epsilon 4 allele has been shown to be a risk factor for late onset Alzheimer's disease (AD) where there is an increased frequency of the epsilon 4 allele. The epsilon 4 allele has also been shown to reduce the age at onset of...
Topics
- Alleles
- Alzheimer Disease
- Apolipoproteins E
- Brain
- Dementia
- Genetic Linkage
- Humans