Article
Characterization of the non-functional Fas ligand of gld mice.
International immunology - 1 Sept 1995
Hahne M, Peitsch M C, Irmler M, Schröter M, Lowin B, Rousseau M, Bron C, Renno T, French L, Tschopp J
Abstract excerpt
Mice homozygous for either the gld or lpr mutation develop autoimmune diseases and progressive lymphadenopathy. The lpr mutation is characterized by the absence of functional Fas, whereas gld mice exhibit an inactive FasL due to a point mutation proximal to the extracellular C-terminus. The structural repercussions of this amino acid substitution remain unknown. Here we report that FasL is expressed at similar...
Topics
- Amino Acid Sequence
- Animals
- Autoimmune Diseases
- Base Sequence
- Fas Ligand Protein
- Humans
- Membrane Glycoproteins
- Mice
- Mice, Mutant Strains
- Molecular Sequence Data
- Mutation