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Article

Effects of hemizygous CD45 expression in the autoimmune Fasl(gld/gld) syndrome.

Cellular immunology - 25 Aug 2001

Brooks W P, Lynes M A

Abstract excerpt

Mice homozygous for the Fasl(gld/gld) mutation cannot initiate apoptosis via the Fas/Fasl pathway and develop an autoimmune disease characterized by the accumulation of CD4(-)/CD8(-) (DN) T cells and a progressive T cell anergy. These DN T cells express a high-molecular-weight isoform of the membrane PTPase CD45 (B220). We have produced a Fasl(gld/gld) mouse strain with only one functional CD45 allele (CD45(+/-),...

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Source

Identifiers

PMID: 11716526
DOI: 10.1006/cimm.2001.1845

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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