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Article

Autoimmunity in mice bearing lprcg: a novel mutant gene.

International reviews of immunology - 1 Jan 1994

Kimura M, Matsuzawa A

Abstract excerpt

A novel mutation at the lpr (lymphoproliferation)(Fas) locus, lprcg, that can complement gld (generalized lymphoproliferative disease) in induction of lymphadenopathy was discovered in CBA/K1Jms mice. The lpr and lprcg mutations are a defective allele of the Fas locus that encodes an apoptosis-me...

Topics

Alleles
Animals
Autoimmune Diseases
Autoimmunity
Bone Marrow Transplantation
Lymphocyte Activation
Lymphoid Tissue
Lymphoproliferative Disorders
Mice
Mice, Inbred CBA
Mice, Mutant Strains
Phenotype

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Identifiers

PMID: 7930845
DOI: 10.3109/08830189409061727

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7930845-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Autoimmunity in mice bearing lprcg: a novel mutant gene.PMID 7930845Read ↗

A new allele of the lpr locus, lprcg, that complements the gld gene in induction of lymphadenopathy in the mouse.Semantic proximity Read ↗

Distinctive expression of lprcg in the heterozygous state on different genetic backgrounds.Semantic proximity Read ↗

Correction of gld autoimmunity by co-infusion of normal bone marrow suggests that gld is a mutation of the Fas ligand gene.Semantic proximity Read ↗

Lymphadenopathy induced by the cooperation between lprcg and gld genes is of lpr but not of gld phenotype.Semantic proximity Read ↗

Loci predisposing to autoimmunity in MRL-Fas lpr and C57BL/6-Faslpr mice.Semantic proximity Read ↗

lpr And gld: Single Gene Models Of Systemic Autoimmunity And Lymphoproliferative DiseaseSemantic proximity Read ↗

Immunological and pathological consequences of mutations in both Fas and Fas ligand.Semantic proximity Read ↗

<i>Lpr</i> and <i>gld</i>: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative DiseaseSemantic proximity Read ↗

The lpr and gld genes in systemic autoimmunity: life and death in the Fas lane.Semantic proximity Read ↗

Genotype-restricted lymphoproliferation in autoimmune lpr mice.Semantic proximity Read ↗

Impact of loss of NF-κB1, NF-κB2 or c-REL on SLE-like autoimmune disease and lymphadenopathy in Fas(lpr/lpr) mutant mice.Semantic proximity Read ↗

Immunological characterization of C3H mice congenic for Fas(lprcg), C3h/HeJ-Fas(lprcg)/Fas(lprcg).Semantic proximity Read ↗

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