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Article

gld/gld mice are unable to express a functional ligand for Fas.

European journal of immunology - 1 Apr 1994

Ramsdell F, Seaman M S, Miller R E, Tough T W, Alderson M R, Lynch D H

Abstract excerpt

Mice homozygous for either the lpr or gld genes develop phenotypically identical autoimmune disorders. The gene responsible for the pathology in lpr/lpr mice encodes the Fas antigen, a protein associated with the induction of programmed cell death. To determine if the defect associated with gld represents a mutation in the ligand for Fas, we have assessed the ability of lymphoid cells from homozygous gld/gld mice...

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Source

Identifiers

PMID: 7512035
DOI: 10.1002/eji.1830240422

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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gld/gld mice are unable to express a functional ligand for Fas.PMID 7512035Read ↗

Functional distinctions between MRL-lpr and MRL-gld lymphocytes. Normal cells reverse the gld but not lpr immunoregulatory defect.Semantic proximity Read ↗

Correction of gld autoimmunity by co-infusion of normal bone marrow suggests that gld is a mutation of the Fas ligand gene.Semantic proximity Read ↗

Immunological and pathological consequences of mutations in both Fas and Fas ligand.Semantic proximity Read ↗

Characterization of the non-functional Fas ligand of gld mice.Semantic proximity Read ↗

Complete loss of Fas ligand gene causes massive lymphoproliferation and early death, indicating a residual activity of gld allele.Semantic proximity Read ↗

Fas and Fas ligand: lpr and gld mutations.Semantic proximity Read ↗

Membrane-bound Fas ligand only is essential for Fas-induced apoptosis.Semantic proximity Read ↗

Autoimmunity in mice bearing lprcg: a novel mutant gene.Semantic proximity Read ↗

Spontaneous development of plasmacytoid tumors in mice with defective Fas-Fas ligand interactions.Semantic proximity Read ↗

Effects of hemizygous CD45 expression in the autoimmune Fasl(gld/gld) syndrome.Semantic proximity Read ↗

lpr And gld: Single Gene Models Of Systemic Autoimmunity And Lymphoproliferative DiseaseSemantic proximity Read ↗

Autoimmune gld mutation uncouples suicide and cytokine/proliferation pathways in activated, mature T cells.Semantic proximity Read ↗

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