Article
gld/gld mice are unable to express a functional ligand for Fas.
European journal of immunology - 1 Apr 1994
Ramsdell F, Seaman M S, Miller R E, Tough T W, Alderson M R, Lynch D H
Abstract excerpt
Mice homozygous for either the lpr or gld genes develop phenotypically identical autoimmune disorders. The gene responsible for the pathology in lpr/lpr mice encodes the Fas antigen, a protein associated with the induction of programmed cell death. To determine if the defect associated with gld r...
Topics
- Animals
- Antigens, Surface
- Autoimmune Diseases
- Cytotoxicity, Immunologic
- Ligands
- Lymph Nodes
- Lymphoproliferative Disorders
- Mice
- Mice, Inbred C3H
- Mice, Inbred DBA
- Mutation
- T-Lymphocyte Subsets
- fas Receptor