Article
Immunological and pathological consequences of mutations in both Fas and Fas ligand.
Cellular immunology - 25 May 1998
Weintraub J P, Godfrey V, Wolthusen P A, Cheek R L, Eisenberg R A, Cohen P L
Abstract excerpt
The lpr mutation in mice results in premature termination of transcription of the gene encoding the apoptosis-signaling receptor Fas. As a result, lpr mice develop severe lymphoproliferation and lupus-like autoantibodies. Growing evidence suggests that the lpr mutation is "leaky" and that low levels of Fas are expressed in lpr mice. To determine if Fas expressed in lpr mice is contributing to apoptosis we...
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