Article
Immunological and pathological consequences of mutations in both Fas and Fas ligand.
Cellular immunology - 25 May 1998
Weintraub J P, Godfrey V, Wolthusen P A, Cheek R L, Eisenberg R A, Cohen P L
Abstract excerpt
The lpr mutation in mice results in premature termination of transcription of the gene encoding the apoptosis-signaling receptor Fas. As a result, lpr mice develop severe lymphoproliferation and lupus-like autoantibodies. Growing evidence suggests that the lpr mutation is "leaky" and that low lev...
Topics
- Animals
- Apoptosis
- Autoantibodies
- Autoimmunity
- Crosses, Genetic
- Fas Ligand Protein
- Female
- Genotype
- Liver
- Lymphatic Diseases
- Male
- Membrane Glycoproteins
- Mice
- Mice, Inbred C57BL
- Mice, Inbred MRL lpr
- Mutation
- Polymerase Chain Reaction
- fas Receptor