Article
Correction of gld autoimmunity by co-infusion of normal bone marrow suggests that gld is a mutation of the Fas ligand gene.
International immunology - 1 Oct 1993
Sobel E S, Kakkanaiah V N, Cohen P L, Eisenberg R A
Abstract excerpt
lpr and gld mice develop phenotypically indistinguishable systemic autoimmune diseases and marked lymphadenopathy dominated by CD4-CD8- T cells. In vivo chimera experiments have demonstrated that both lpr T and lpr B cells are intrinsically defective. Analogous experiments were conducted using gld mice. Lethally irradiated gld mice were given mixtures of congenic gld and normal (+/+) bone marrow differentially...
Topics
- Animals
- Antigens, Surface
- Apoptosis
- Autoimmune Diseases
- Bone Marrow Transplantation
- CD4 Antigens
- CD8 Antigens
- Immunoglobulin G
- Immunoglobulin M
- Lymphoproliferative Disorders
- Mice