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Article

Tumor necrosis factor sustains the generalized lymphoproliferative disorder (gld) phenotype.

The Journal of experimental medicine - 3 Jan 2000

Körner H, Cretney E, Wilhelm P, Kelly J M, Röllinghoff M, Sedgwick J D, Smyth M J

Abstract excerpt

Tumor necrosis factor (TNF) and Fas ligand (FasL) play major roles in the homeostasis of the peripheral immune system. This becomes dramatically obvious in the absence of a functional FasL. Mice with such a deficiency develop a profound lymphadenopathy, splenomegaly, hypergammaglobulinemia, and strain-dependent systemic autoimmune disease, and succumb to premature death. It is consequently termed generalized...

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Share to Mice, Inbred C3H
Share to Antibodies, Monoclonal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Antigens, CD

Share to Fas Ligand Protein

Share to Germinal Center

Share to Lymphoproliferative Disorders

Share to Receptors, Tumor Necrosis Factor

Share to Receptors, Tumor Necrosis Factor, Type II

Source

Open in PubMed Open full text

Identifiers

PMID: 10620607
DOI: 10.1084/jem.191.1.89
PMCID: PMC2195803

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Tumor necrosis factor sustains the generalized lymphoproliferative disorder (gld) phenotype.PMID 10620607Read ↗

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