Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fas and Fas ligand: lpr and gld mutations.

Immunology today - 1 Jan 1995

Nagata S, Suda T

Abstract excerpt

Fas ligand (FasL) is a death factor that binds to its receptor, Fas, and induces apoptosis. Two mutations that accelerate autoimmune disease, lpr and gld, are known to correspond to mutations within genes encoding Fas and FasL, respectively. Here, Shigekazu Nagata and Takashi Suda summarize current knowledge of Fas and FasL, and discuss the physiological role of the Fas system in T-cell development, cytotoxicity...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Apoptosis
Share to Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Mutant Strains

Share to Molecular Sequence Data

Share to Mutation

Share to T-Lymphocytes

Source

Identifiers

PMID: 7533498
DOI: 10.1016/0167-5699(95)80069-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fas and Fas ligand: lpr and gld mutations.PMID 7533498Read ↗

Missense mutations in the Fas gene resulting in autoimmune lymphoproliferative syndrome: a molecular and immunological analysis.Semantic proximity Read ↗

Human autoimmune lymphoproliferative syndrome, a defect in the apoptosis-inducing Fas receptor: a lesson from the mouse model.Semantic proximity Read ↗

Missense Mutations in the Fas Gene Resulting in Autoimmune Lymphoproliferative Syndrome: A Molecular and Immunological AnalysisSemantic proximity Read ↗

Autoimmune lymphoproliferative syndrome: molecular basis of disease and clinical phenotype.Semantic proximity Read ↗

Membrane-bound Fas ligand only is essential for Fas-induced apoptosis.Semantic proximity Read ↗

Immunological and pathological consequences of mutations in both Fas and Fas ligand.Semantic proximity Read ↗

Biology of FasL.Semantic proximity Read ↗

Autoimmune lymphoproliferative syndrome caused by a homozygous FasL mutation that disrupts FasL assembly.Semantic proximity Read ↗

Analysis of gene profile, steady state proliferation and apoptosis of double-negative T cells in the periphery and gut epithelium provides new insights into the biological functions of the Fas pathway.Semantic proximity Read ↗

Revisiting autoimmune lymphoproliferative syndrome caused by Fas ligand mutations.Semantic proximity Read ↗

Lupus in the Fas lane?Semantic proximity Read ↗

A genetic disorder of lymphocyte apoptosis involving the fas pathway: the autoimmune lymphoproliferative syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.