Fas and Fas ligand: lpr and gld mutations.

Abstract excerpt

Fas ligand (FasL) is a death factor that binds to its receptor, Fas, and induces apoptosis. Two mutations that accelerate autoimmune disease, lpr and gld, are known to correspond to mutations within genes encoding Fas and FasL, respectively. Here, Shigekazu Nagata and Takashi Suda summarize current knowledge of Fas and FasL, and discuss the physiological role of the Fas system in T-cell development, cytotoxicity...

Topics

• Amino Acid Sequence
• Animals
• Antigens, Surface
• Apoptosis
• Autoimmune Diseases
• Base Sequence
• Ligands
• Lymphoproliferative Disorders
• Mice
• Mice, Mutant Strains
• Molecular Sequence Data
• Mutation