Article
Functional distinctions between MRL-lpr and MRL-gld lymphocytes. Normal cells reverse the gld but not lpr immunoregulatory defect.
Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 1994
Ettinger R, Wang J K, Bossu P, Papas K, Sidman C L, Abbas A K, Marshak-Rothstein A
Abstract excerpt
Homozygosity for either of the autosomal recessive mutations, lpr or gld, confers an autoimmune syndrome characterized by massive lymphoid hyperplasia and extensive autoantibody production. Despite the similarities in disease progression, functional distinctions in these genetic defects have been observed in bone marrow transplantation studies. To elucidate the mechanisms responsible for the aberrant immune...
Topics
- Animals
- Autoimmune Diseases
- Cells, Cultured
- Lymph Nodes
- Lymphocyte Activation
- Lymphoproliferative Disorders
- Mice
- Mice, Inbred C3H
- Mutation
- Phenotype
- T-Lymphocytes