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Article

Complete loss of Fas ligand gene causes massive lymphoproliferation and early death, indicating a residual activity of gld allele.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2004

Karray Saoussen, Kress Chantal, Cuvellier Sylvain, Hue-Beauvais Catherine, Damotte Diane, Babinet Charles, Lévi-Strauss Matthieu

Abstract excerpt

To investigate the in vivo function of Fas ligand (FasL), we produced a mouse strain with a FasL gene flanked by loxP sequences. Mice with homozygous floxed FasL gene showed no obvious abnormalities. However, germline deletion of the FasL gene, obtained after mating with mice expressing ubiquitous Cre recombinase, resulted in an unexpectedly severe phenotype. FasL(-/-) mice exhibited an extreme splenomegaly and...

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Identifiers

PMID: 14764677
DOI: 10.4049/jimmunol.172.4.2118

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Complete loss of Fas ligand gene causes massive lymphoproliferation and early death, indicating a residual activity of gld allele.PMID 14764677Read ↗

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Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligandSemantic proximity Read ↗

Correction of gld autoimmunity by co-infusion of normal bone marrow suggests that gld is a mutation of the Fas ligand gene.Semantic proximity Read ↗

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Missense Mutations in the Fas Gene Resulting in Autoimmune Lymphoproliferative Syndrome: A Molecular and Immunological AnalysisSemantic proximity Read ↗

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