Membrane-bound Fas ligand only is essential for Fas-induced apoptosis.

doi:10.1038/nature08402

Article

Membrane-bound Fas ligand only is essential for Fas-induced apoptosis.

Nature - 1 Oct 2009

O' Reilly Lorraine A, Tai Lin, Lee Lily, Kruse Elizabeth A, Grabow Stephanie, Fairlie W Douglas, Haynes Nicole M, Tarlinton David M, Zhang Jian-Guo, Belz Gabrielle T, Smyth Mark J, Bouillet Philippe, Robb Lorraine, Strasser Andreas

Abstract excerpt

Fas ligand (FasL), an apoptosis-inducing member of the TNF cytokine family, and its receptor Fas are critical for the shutdown of chronic immune responses and prevention of autoimmunity. Accordingly, mutations in their genes cause severe lymphadenopathy and autoimmune disease in mice and humans. FasL function is regulated by deposition in the plasma membrane and metalloprotease-mediated shedding. Here we...

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Membrane-bound Fas ligand only is essential for Fas-induced apoptosis.

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Membrane-bound Fas ligand only is essential for Fas-induced apoptosis.

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