Locus-specific stratification and prioritization unveil genetic risk mechanism underlying complex diseases.

doi:10.1038/s41467-026-76649-3

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Article

Locus-specific stratification and prioritization unveil genetic risk mechanism underlying complex diseases.

Nature communications - 18 Aug 2026

Zhang Jing, Liu Qiaoqiao, Zhu Yeping, Xia Limei, Wang Kangchun, Guo Yue, Gong Luyu, Liu Zhaojun, Qin Zhaohui, Shi Shaolin, Yang Jingping

Abstract excerpt

Although genome-wide association studies have identified thousands of disease-associated loci, the mechanistic understanding and drug target discovery remain challenging, particularly for complex diseases. The multi-signal architecture of complex diseases complicates the interpretation of genetic contributions. To address this challenge, we develop an approach comprising locus-specific stratification (LSS) and...

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Topics

Genetic Risk Score
Sodium-Phosphate Cotransporter Proteins, Type I
Humans
Genome-Wide Association Study
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Uric Acid

Genetic Loci

Gene Expression Regulation

Gene Regulatory Networks

Molecular Targeted Therapy

Biological Transport

Hyperuricemia

Single-Cell Gene Expression Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 42749723
DOI: 10.1038/s41467-026-76649-3
PMCID: PMC13582940

Genes

LSS
SLC17A4

Provenance

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