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Article

GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background.

eLife - 15 Feb 2021

Sinnott-Armstrong Nasa, Naqvi Sahin, Rivas Manuel, Pritchard Jonathan K

Abstract excerpt

Genome-wide association studies (GWAS) have been used to study the genetic basis of a wide variety of complex diseases and other traits. We describe UK Biobank GWAS results for three molecular traits-urate, IGF-1, and testosterone-with better-understood biology than most other complex traits. We find that many of the most significant hits are readily interpretable. We observe huge enrichment of associations near...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33587031
DOI: 10.7554/eLife.58615
PMCID: PMC7884075

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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