Article

GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background

2020-04-22

Abstract excerpt

<h4>Summary</h4> Genome-wide association studies (GWAS) have been used to study the genetic basis of a wide variety of complex diseases and other traits. We describe UK Biobank GWAS results for three molecular traits—urate, IGF-1, and testosterone—with better-understood biology than most other complex traits. We find that many of the most significant hits are readily and surprisingly interpretable. We observe hug...

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Literature Corpus work: 08942f0a-c5ae-5c23-946d-d2ffeba3b289
DOI: 10.1101/2020.04.20.051631

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