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Modeling the genetic architecture of complex traits via stratified high-definition likelihood

2024-11-12

Abstract excerpt

<title>Abstract</title> <p>The distribution of heritability across the genome describes how the underlying genetic architecture of complex traits is shaped. Using genome-wide summary association statistics, state-of-the-art techniques analyze the heritability distribution by stratifying the genome based on functional annotations. We present the stratified high-definition likelihood (sHDL) method, an advanced stat...

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Literature Corpus work: 0f2a9bac-4b93-5ca0-ba5f-dff8b65c932e
DOI: 10.21203/rs.3.rs-5204355/v1

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