Article
Large-scale cross-ancestry genome-wide meta-analysis of serum urate.
Nature communications - 24 Apr 2024
Cho Chamlee, Kim Beomsu, Kim Dan Say, Hwang Mi Yeong, Shim Injeong, Song Minku, Lee Yeong Chan, Jung Sang-Hyuk, Cho Sung Kweon, Park Woong-Yang, Myung Woojae, Kim Bong-Jo, Do Ron, Choi Hyon K, Merriman Tony R, Kim Young Jin, Won Hong-Hee
Abstract excerpt
Hyperuricemia is an essential causal risk factor for gout and is associated with cardiometabolic diseases. Given the limited contribution of East Asian ancestry to genome-wide association studies of serum urate, the genetic architecture of serum urate requires exploration. A large-scale cross-ancestry genome-wide association meta-analysis of 1,029,323 individuals and ancestry-specific meta-analysis identifies a...
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