Article

Genomic dissection of 43 serum urate-associated loci provides multiple insights into molecular mechanisms of urate control

2019-08-22

Abstract excerpt

Serum urate is the end-product of purine metabolism. Elevated serum urate is causal of gout and a predictor of renal disease, cardiovascular disease and other metabolic conditions. Genome-wide association studies (GWAS) have reported dozens of loci associated with serum urate control, however there has been little progress in understanding the molecular basis of the associated loci. Here we employed trans-ancestra...

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Literature Corpus work: 98ff94a5-4476-5661-8453-2fa318d6afff
DOI: 10.1101/743864

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