Article

Locus-specific stratification and prioritization unveil high risk genes underlying hyperuricemia

2024-03-08

Abstract excerpt

The development of alternative medications for urate-lowering therapies is imperative for patients that are intolerant to current treatments. Despite GWAS have identified hundreds of loci associated with serum urate levels, the mechanistic understanding and discovery of drug targets remain difficult. This difficulty arises from the multiple-independent-associations challenge in the genomic studies of complex disea...

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Literature Corpus work: 76dcea89-4b6b-59fb-93db-1d0c084a098c
DOI: 10.1101/2024.03.06.24303846

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