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Genomic dissection of 43 serum urate-associated loci provides multiple insights into molecular mechanisms of urate control.

Human molecular genetics - 15 Apr 2020

Boocock James, Leask Megan, Okada Yukinori, Matsuo Hirotaka, Kawamura Yusuke, Shi Yongyong, Li Changgui, Mount David B, Mandal Asim K, Wang Weiqing, Cadzow Murray, Gosling Anna L, Major Tanya J, Horsfield Julia A, Choi Hyon K, Fadason Tayaza, O'Sullivan Justin, Stahl Eli A, Merriman Tony R

Abstract excerpt

High serum urate is a prerequisite for gout and associated with metabolic disease. Genome-wide association studies (GWAS) have reported dozens of loci associated with serum urate control; however, there has been little progress in understanding the molecular basis of the associated loci. Here, we employed trans-ancestral meta-analysis using data from European and East Asian populations to identify 10 new loci for...

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PMID: 31985003
DOI: 10.1093/hmg/ddaa013

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