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Article

Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

1 Oct 2019

Abstract excerpt

Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via poorly understood mechanisms. We performed a trans-ancestry genome-wide association study of serum urate in 457,690 individuals, identifying 183 loci (147 previously unknown) that improve the prediction of gout in an independent cohort of 334,880 individuals. Serum urate showed significant genetic correlations with many...

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Share to Gout, Hyperuricemia, Uric Acid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 31578528
DOI: 10.1038/s41588-019-0504-x

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