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Article

The genetic basis of urate control and gout: Insights into molecular pathogenesis from follow-up study of genome-wide association study loci.

Best practice & research. Clinical rheumatology - 1 Dec 2021

Leask Megan P, Merriman Tony R

Abstract excerpt

This review focuses on the post-genome-wide association study (GWAS) era in gout, i.e., the translation of GWAS genetic association signals into biologically informative knowledge. Analytical and experimental follow-up of individual loci, based on the identification of causal genetic variants, reveals molecular pathogenic pathways. We summarize in detail the largest GWAS in urate to date, then we review follow-up...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34732286
DOI: 10.1016/j.berh.2021.101721

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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