Article

Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases

2020-09-10

Abstract excerpt

<h4>ABSTRACT</h4> Genome-wide association studies (GWAS) are a valuable tool for understanding the biology of complex traits, but the associations found rarely point directly to causal genes. Here, we introduce a new method to identify the causal genes by integrating GWAS summary statistics with gene expression, biological pathway, and predicted protein-protein interaction data. We further propose an approach that...

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Literature Corpus work: 0df997bb-e54b-5386-a6d0-7e31528ce359
DOI: 10.1101/2020.09.08.20190561

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