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Article

Single-cell and genome-wide Mendelian randomization identifies causative genes for gout.

Arthritis research & therapy - 3 Jun 2024

Yang Yubiao, Hu Ping, Zhang Qinnan, Ma Boyuan, Chen Jinyu, Wang Bitao, Ma Jun, Liu Derong, Hao Jian, Zhou Xianhu

Abstract excerpt

BACKGROUND: Gout is a prevalent manifestation of metabolic osteoarthritis induced by elevated blood uric acid levels. The purpose of this study was to investigate the mechanisms of gene expression regulation in gout disease and elucidate its pathogenesis. METHODS: The study integrated gout genome-wide association study (GWAS) data, single-cell transcriptomics (scRNA-seq), expression quantitative trait loci...

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Source

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Identifiers

PMID: 38831441
DOI: 10.1186/s13075-024-03348-z
PMCID: PMC11145851

Genes

KRTCAP2
TRIM46
ADH1B
BMP1
MAP3K11
MTX1
THBS3
TM7SF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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