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Comparative Phenotypic Screening Identifies Protein Synthesis Inhibitors as Compounds That Enhance Early Acidification of Mycobacterium tuberculosis in Macrophages.

ACS infectious diseases - 14 Aug 2026

Rankine-Wilson Leah, Av-Gay Yossef

Abstract excerpt

Treatments for tuberculosis disease (TB) are failing on a global scale, necessitating new drug discovery efforts to identify effective therapies. Mycobacterium tuberculosis (Mtb), the obligate human pathogen and causative agent of TB, resides within alveolar macrophages and combats acidic stress by inhibiting phagosome maturation. Understanding the role of acidification in Mtb pathogenesis can aid the development...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 42384363
DOI: 10.1021/acsinfecdis.6c00093

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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